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	<metsHdr CREATEDATE="2007-09-01T00:00:00">
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			<name>Richard Jones</name>
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				<epdcx:descriptionSet
					xmlns:epdcx="http://purl.org/eprint/epdcx/2006-11-16/"
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							epdcx:valueURI="http://purl.org/eprint/entityType/ScholarlyWork" />
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							epdcx:propertyURI="http://purl.org/dc/elements/1.1/title">
							<epdcx:valueString>
								Attempts to detect retrotransposition
								and de novo deletion of Alus and other
								dispersed repeats at specific loci in
								the human genome
							</epdcx:valueString>
						</epdcx:statement>
						<epdcx:statement
							epdcx:propertyURI="http://purl.org/dc/terms/abstract">
							<epdcx:valueString>
								Dispersed repeat elements contribute to
								genome instability by de novo insertion
								and unequal recombination between
								repeats. To study the dynamics of these
								processes, we have developed single DNA
								molecule approaches to detect de novo
								insertions at a single locus and
								Alu-mediated deletions at two different
								loci in human genomic DNA. Validation
								experiments showed these approaches
								could detect insertions and deletions at
								frequencies below 10(-6) per cell.
								However, bulk analysis of germline
								(sperm) and somatic DNA showed no
								evidence for genuine mutant molecules,
								placing an upper limit of insertion and
								deletion rates of 2 x 10(-7) and 3 x
								10(-7), respectively, in the individuals
								tested. Such re-arrangements at these
								loci therefore occur at a rate lower
								than that detectable by the most
								sensitive methods currently available.
							</epdcx:valueString>
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							epdcx:propertyURI="http://purl.org/dc/elements/1.1/creator">
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								Hollies, C.R.
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							epdcx:propertyURI="http://purl.org/dc/elements/1.1/creator">
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								Monckton, D.G.
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						<epdcx:statement
							epdcx:propertyURI="http://purl.org/dc/elements/1.1/creator">
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								Jeffreys, A.J.
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								http://www.myu.ac.uk/some/identifier
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							<epdcx:valueString>en</epdcx:valueString>
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						<epdcx:statement
							epdcx:propertyURI="http://purl.org/dc/elements/1.1/type"
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							epdcx:valueURI="http://purl.org/eprint/type/JournalArticle" />
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							epdcx:propertyURI="http://purl.org/dc/terms/available">
							<epdcx:valueString
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								2001-02
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							epdcx:propertyURI="http://purl.org/eprint/terms/copyrightHolder">
							<epdcx:valueString>
								Nature Publishing Group
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